|Awarded On||November 19, 2015|
|Title||The CTC Circulator Phenotype: Insights into Mechanisms of Breast Cancer Dormancy|
|Award Mechanism||Individual Investigator|
|Institution/Organization||Baylor College of Medicine|
|Principal Investigator/Program Director||Dario Marchetti|
|Cancer Sites||Brain and Other Nervous System, Breast|
Breast cancer brain metastasis (BCBM) is the most feared consequence of breast cancer with Circulating Tumor Cells (CTCs) being the essential pre-condition for BCBM to occur. CTCs are shed into the vasculature, circulate and survive in the blood, arrest/adhere at distant organ sites, and extravasate at the target organs to generate metastasis. Importantly, higher than 67% of deaths in breast cancer patients occur after a 5-year survival mark and residual disease can be dormant for periods longer than 20 years. The patients are asymptomatic because CTCs appear to become dormant and are undetectable by clinical tools. Further, rates of CTC survival can be highly variable, lasting less few...