|Grant ID: RR190058|
Recruitment of Rising Stars
University of North Carolina Lineberger Comprehensive Cancer Center
May 15, 2019
As they grow, cells buried in the center of a solid tumor outstrip the available oxygen supply. But rather than dying, these cells thrive under low-oxygen conditions. This superpower enables some cancer cells to survive treatments designed to kill them.
But their survival under hypoxic conditions may prove an Achilles heel if biochemist Qing Zhang can figure out the genes and enzymes that grant these cells immortality.
Zhang was recruited in 2019 to the University of Texas Southwestern Medical Center Department of pathology. He was associate professor at Lineberger Comprehensive Cancer Center at the University of North Carolina School of Medicine, and was recruited with the help of a Rising Star award from CPRIT.
As a tumor grows, it begins as a single cell and multiplies to form a larger tumor that can be thought of as a ball shape. Blood vessels can only supply the surface of the ball, so the center becomes more and more deprived of oxygen.